Host: Rabbit 

Clonality: Polyclonal 

GeneID: 860 

Target: RUNX2 

Isotype: IgG 

SWISS: Q13950 

Applications: WB (1:500-2000) IHC-P (1:100-500) IHC-F (1:100-500) IF (1:100-500) Flow-Cyt (1ug/Test)

Reactivity: Human, Mouse, Rat (predicted: Rabbit, Pig, Sheep, Cow, Chicken, Dog, Horse) 

Predicted MW.: 57(hu)/67(mo,rat) kDa 

Observed MW.: 62 kDa 

Subcellular Location: Nucleus

Immunogen: KLH conjugated synthetic peptide derived from human RUNX2: 202-300/521. 

Purification: affinity purified by Protein A 

Concentration: 1mg/ml 

Storage: 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. 

Background: This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008].

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